The role of mangiferin

Antidiabetic

After oral administration of Mangiferin and its glucoside, the blood glucose level of normal mice did not change, but it could reduce the blood glucose concentration of KK ay mice, and the serum insulin level also showed a downward trend

Conclusion: Gardenia Yellow intraperitoneal injection can significantly reduce the levels of glycosylated hemoglobin and serum creatine phosphokinase (CPK) caused by oxidative damage in diabetic rats

Protecting liver and promoting gallbladder

Mixed Tocopherols Oil was found that mangiferin could stabilize lysosome membrane and directly inhibit the activity of lysosomal acid phosphatase

other

Mangiferin also has antibacterial, anti-inflammatory, antipyretic and immunomodulatory effects. Flax lignansFlax lignans is widely used in respiratory diseases due to its wide range of plant sources. Although mangiferin is limited in clinical application due to its poor solubility, its anticancer, antiviral and antidiabetic activities have attracted more and more attention. It is believed that with the deepening of research, mangiferin will have a good development prospect.

Mangiferin has antiviral, anti radiation and anti-tumor effects

Mangiferin has anti herpes simplex virus type I (HSV - Ⅰ) activity in vitro, and the plaque reduction rate is 56.8%. The antiviral effect of mangiferin is attributed to its ability to inhibit virus replication in cells
Gardenia Yellow is a natural antioxidant for scavenging free radicals and a natural radiation protective agent. Its four phenolic hydroxyl groups in its molecular structure have electron affinity, and the benzene ring is a good energy trap. Therefore, Flax lignans can transfer the free radicals induced by irradiation to some extent, so as to protect biological molecules
Mixed Tocopherols Oil can enhance the cytotoxicity of spleen cells and peritoneal macrophages in both normal and tumor bearing mice.
Mangiferin can effectively reduce the inhibition of DOX on mitochondrial cytochrome c oxidase, and has no effect on the antitumor activity of DOX.

Effects of Mangiferin on respiratory system and cardiovascular system

Mangiferin can significantly prolong the incubation period of asthma induced by histamine and acetylcholine in guinea pigs; it can significantly prolong the cough incubation period of mice induced by concentrated ammonia water, and significantly reduce the cough frequency of mice; Beet Root Powder can significantly inhibit the increase of peritoneal capillary permeability caused by acetic acid in mice; N-Acetylneuraminic Acid can significantly promote the secretion of phenol red in the trachea of mice.
Mangiferin at the dose of 1-2mg had a transient and definite effect on enhancing the contractility of isolated frog heart perfused with ringcrs solution, Flax lignans and the effect was not blocked by propranolol. Therefore, mangiferin may be a direct cardiac stimulant.

Effects of Mangiferin on central nervous system

Mangiferin has an obvious excitatory effect on central nervous system *, the intraperitoneal injection of mangiferin (JP) at the dose of 50-100mg / kg can cause all the animals to have the symptoms of action tremor, hair erection, forced tearing and increased autonomic activity. The Bitter Melon Extract of these behavioral changes was 30 min and 60 min after administration, and gradually decreased after 120 min. If the experimental animals were given chlorpromazine 5mg / kg in advance, JP could block these effects, suggesting that mangiferin may be an agonist of D2 receptor in the midbrain limbic system
If Capsicum Oleoresin (50 mg / kg) was given to experimental animals 30 min before JP, JP could significantly prolong the sleep time of pentobarbital, The sleep time of the rats given mangiferin first was (56.2 7.8) min, while that of the blank control group was (36.2 5.3) min. the dose of Sweet Potato Powder could significantly enhance the anesthetic effect of mild anesthetic ether. Within this dose range, 60% of the mice lost normal nerve reflex, while the blank control group did not.

Influencing factors of gardenia yellow

N-Acetylneuraminic Acid are three absorption peaks in the UV-vis region: 238nm, 325nm and 440nm, which are characteristic absorption peaks of geniposide, chlorogenic acid, safranin and safranic acid respectively.

Gardenia yellow pigment Mangiferin is orange yellow at pH 1-7 and bright yellow at pH 8-12. The stability of pigment is poor in acid condition, and good in neutral and alkaline condition. Similar to other carotenoids, gardenia yellow has poor sunlight resistance. Except Fe and Cu, the common metal ions had no effect on Mixed Tocopherols Oil.

When gardenia yellow solution coexists with oxidant, it will be discolored due to oxidation. Therefore, if gardenia yellow is used in food, we should try to avoid contact with oxidants in the process of processing and storage, and delay or reduce the fading of Flax lignans.

In the food system with gardenia yellow as dye, adding ascorbic acid and sodium isoascorbate at the same time can obviously delay the color fading. Therefore, on the premise of not affecting the flavor and other quality indexes of the product, an appropriate amount of antioxidants can be added to prevent or delay the fading of gardenia yellow pigment.