Indole-3-methanol in vegetables may block the production of colon cancer(2)

Gut reaction

The AhR ACTS as an environmental sensor, transmitting signals to immune and epithelial cells in the intestinal wall that protect us from inflammatory responses to the trillions of bacteria that live in the gut(3 Carbinol).

"We studied mice that were genetically modified not to produce or activate AhR in the gut, and found that they were prone to inflammation of the gut that progresses to colon cancer," explained lead author Amina Metidji, Indole-3-Carbinol, of the Francis crick institute. However, when we fed them a diet rich in I3C, they did not develop intestinal inflammation and did not develop colon cancer. Interestingly, when mice with colon cancer switched to an i3c-rich diet, they also ended up with significantly fewer tumours and Herbal Products."

By studying mice and their gut organoid, a "mini gut" made from stem cells, the researchers found that AhR is crucial for repairing damaged epithelial cells. Without AhR, intestinal stem cells cannot differentiate into specialized epithelial cells that take in nutrients or produce protective mucus. Instead, they divide uncontrollably, which can eventually lead to colon cancer(Herbal Extract Supplier).