Anti radiation effect of ferulic acid

Radiation induced organ failure is largely caused by chronic peroxide damage. Radiation damage to the body can be divided into direct damage and Mangiferin. Direct damage directly causes the breakage of some sensitive molecules in the cell; indirect damage causes the radiolysis of water, which leads to the increase of intracellular reactive oxygen species and the change of subcellular structure. Therefore, antioxidants are widely used in the treatment of radiation injury. In order to protect cells from reactive oxygen species (ROS), it is necessary to maintain stable endogenous sulfhydryl pool, especially glutathione (Gardenia Yellow) and nicotinamide adenine dinucleotide phosphate (NADPH). Glutathione provides reduction equivalent for the conversion of hydrogen peroxide and lipid peroxide into water and lipid alcohol, and protects the sulfhydryl protein group from oxidative damage. The rate limiting reaction of glutathione biosynthesis is catalyzed by glutamate cysteine ligase (Flax lignans), which is composed of a catalytic subunit (GCLC) and a regulatory subunit (GCLM). Nicotinamide adenine dinucleotide phosphate is an important antioxidant component in tissues. It can maintain the redox potential of cells by reducing the reduction equivalent of glutathione reductase and thioredoxin.
As a phenolic plant component, Ferulic Acid has strong antioxidant activity, which has a great promoting effect on human health. Ferulic acid can significantly increase the content of glutathione and nicotinamide adenine dinucleotide phosphate in radiation-induced endothelial cells, which has protective effect on irradiated endothelial cells. Heme oxygenase is an antioxidant enzyme. It can convert heme into biliverdin, and finally into antioxidant bilirubin. Ferulic acid can regulate the expression of heme oxygenase, thus playing a protective role in radiation protection.