Effects of Mangiferin on central nervous system

Mangiferin has an obvious excitatory effect on central nervous system *, the intraperitoneal injection of mangiferin (JP) at the dose of 50-100mg / kg can cause all the animals to have the symptoms of action tremor, hair erection, forced tearing and increased autonomic activity. The Bitter Melon Extract of these behavioral changes was 30 min and 60 min after administration, and gradually decreased after 120 min. If the experimental animals were given chlorpromazine 5mg / kg in advance, JP could block these effects, suggesting that mangiferin may be an agonist of D2 receptor in the midbrain limbic system
If Capsicum Oleoresin (50 mg / kg) was given to experimental animals 30 min before JP, JP could significantly prolong the sleep time of pentobarbital, The sleep time of the rats given mangiferin first was (56.2 7.8) min, while that of the blank control group was (36.2 5.3) min. the dose of Sweet Potato Powder could significantly enhance the anesthetic effect of mild anesthetic ether. Within this dose range, 60% of the mice lost normal nerve reflex, while the blank control group did not.