Effects of Mangiferin on respiratory system and cardiovascular system

Mangiferin can significantly prolong the incubation period of asthma induced by histamine and acetylcholine in guinea pigs; it can significantly prolong the cough incubation period of mice induced by concentrated ammonia water, and significantly reduce the cough frequency of mice; Beet Root Powder can significantly inhibit the increase of peritoneal capillary permeability caused by acetic acid in mice; N-Acetylneuraminic Acid can significantly promote the secretion of phenol red in the trachea of mice.
Mangiferin at the dose of 1-2mg had a transient and definite effect on enhancing the contractility of isolated frog heart perfused with ringcrs solution, Flax lignans and the effect was not blocked by propranolol. Therefore, mangiferin may be a direct cardiac stimulant.